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Spinal Cord Electrical Stimulation for Obesity: A Preliminary Rodent Study (99)

Geng-Qing Song, Veterans Research and Education Foundation, Oklahoma City, OK; Jiande Chen, MD PhD, Veterans Research and Education Foundation, Oklahoma City, OK

Introduction: Spinal cord electrical stimulation (SCS) has been applied for the management of chronic pain . Most studies have revealed a decrease in sympathetic activity with SCS . In this study, we hypothesize that SCS with appropriate parameters and specific locations might increase sympathetic activity (causing an increase in metabolism and thus a decrease in body weight) and inhibited gastrointestinal motility (leading to early satiety with reduced food intake) .

Aims: The aim of this study was to investigate the effect of SCS on heart rates, sympathetic activity, serum norepinephrine, gastric emptying, and food intake in rats .

Methods: Male rats chronically implanted with SCS electrodes at T1/T2 or T5/T6 were studied in three experiments . Experiment 1 was to study the effects of SCS with different parameters and locations on heart rates, sympathetic activity . Experiment 2 was to assess the effect of SCS on serum norepinephrine and gastric emptying . Experiment 3 was to assess the effects of SCS on food intake . The animals received 5 days of either sham-SCS or SCS in a randomized order .

Results: (1) SCS at T1-T2 or T5-T6 of the 90% MT, 0 .1 ms, 100 Hz (but not 20 or 80 Hz) increased heart rates and sympathova- gal balance . Heart rate was 462 .4 ± 8 .2 beats/min or 466 .0 ± 9 .7 beats/min at baseline and increased to 477 .8 ± 9 .5 beats/min
(P = 0 .011, SCS at T1/T2) or 479 .9 ± 9 .8 beats/min (P = 0 .013, SCS at T1/T2), respectively . Similarly, the sympathovagal balance was 0 .43 ± 0 .03 or 0 .46 ± 0 .04 at baseline and increased to 0 .50 ± 0 .06 (P = 0 .018, SCS at T1/T2) or 0 .51 ± 0 .03 (P = 0 .012, SCS at T5/T6) , respectively . (2) SCS at T1-T2 or T5-T6 of the 90% MT, 0 .1 ms, 100 Hz increased serum norepinephrine by 98 .8% or 100 .8%, respectively, in comparison with baseline before SCS . (3) SCS at T5-T6 but not T1-T2 of the 90% MT, 0 .1 ms, 100 Hz de- layed gastric emptying . Gastric emptying was 60 .0% ± 3 .7% in the controls and decreased to 50 .4% ± 4 .8% with SCS at T5-T6 (P = 0 .042, vs . controls) . (4) SCS at T5-T6 of the 90% MT, 0 .1 ms, 100 Hz reduced daily food intake by 17 .8% (P = 0 .046) .

Conclusion: SCS at T5-T6 with appropriate parameters reduces food intake in regular rats and the inhibitory effect may attrib- uted to increased sympathetic activity and reduced gastric emptying . Further studies are warranted to explore the potential of SCS for obesity .

Disclosures: J. Chen: None . G. Song: None .

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On paper it looks like the Buccaneers have the sting against the Seahawks with Tampa’s rushing offense being the strongest match. Fortunately for fans, games are played on the 100-yard field by 22 highly proficient football players where paper has little influence.

The Sun Dome can be found at on the University of South Florida’s Tampa grounds. The Sun Dome usually hosts the USF basketball team, but over the weekend just before the Super Bowl this venue is turned into a concert hall and breakfast group. On Friday, January 30th Gospel fans can enjoy the Super Bowl Gospel Blowout. On Saturday, January 31st the sun Dome is host into the popular Super Bowl Breakfast. The Super Bowl Breakfast has gained a reputation getting one of the most useful pre-game events. nfl coaches and players, including Tony Dungy and Derrick Brooks, offer inspiring words and present the 2009 Bart Starr Award honoring an nfl player with outstanding spirit.

A Cypress Bay (FL) High School football coach was suspended for striking his QB in the helmet wholesale official jerseys for overthrowing his receiver. The incident happened on 8/25 and can be seen listed here. I’m on fences on even when he want been suspended for these actions but in

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Desean Jackson can have Philadelphia fans feeling euphoric one moment and infuriated the afterwards. Sometimes all wholesale authentic jerseys with in five minutes. Jackson is flamboyant and fast. He’ll be able to burn an opposing player deep as quick because he can use wholesale nfl jerseys a crossing route untouched home buyers middle. Jackson suffered a concussion this year and it limited his playing time. Even with the limited playing time Jackson had 1167 yards receiving on just 63 catches. Jackson had two touchdown returns to choose his nine touchdowns gaining. If Jackson can stay healthy still look for him to shatter some records.

But putting God first and thanking Him for options Christian players He has put on the team to Wholesale NFL Jerseys Free Shipping Offer encourage younger kids to love God even while they compete in exercises.

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The two keys into a successful draft in fantasy football are: 1) Selecting players who will perform better than expected; and 2) Staying away from cheap authentic stitched nhl jerseys guys who will let you down. In this team series I examine at home wholesale Jerseys Paypal of players on every NFL team as the clubs prepare to look at training camp. For an index of all 32 capsules, follow this link.

There basically six Baseball teams which don’t display the their city on the away game jerseys and Philadelphia is one of them. the others are the Orioles, Angels, Brewers, Cardinals, and Rays.

In Week 7 of fantasy football, the predictions are just a little easier with six teams returning into the field of play after a bye week in Week 6. Three of my picks will be going to be extremely obvious, and I have one fantasy football sleeper for you as carefully. The match-ups in fantasy football Week 7 are very favorable due to guys advertise them easy Week 7 picks.

Aside from that, Newton’s declaration Thursday that cheap baseball jerseys they will enter the nfl draft caused no jaws to fall. After all, his stock cannot get any higher. wholesale nhl jerseys China Despite him, the Tigers can get gone 8-4 next season in the brutal Securities and exchange commission’s. He mastered Gus Malzahn’s complex offense in one season. He will not get any bigger or stronger.

Congrats to Kurt and Sherry Bishop on their recent house warming. May you have just the number of more. A congrats visit the Bishops for individuals effort they are putting forth to rebuild and remodel THE ALIBI. If you have not checked it out, you should, especially if you dig karaoke. Eventually we all need an Alibi.right?

Steelers running back coach Kirby Wilson wants review package from his running backs: capacity to carry the ball, to have the ability to protect the quarterback and to get as great at the first quarter although are typically the fourth. In the Steelers’ mandatory minicamp, Bell called last quarter grind time. That’s when an individual to take it home, said Bell. That’s when nonstop your team is in order to look for to make plays, which happens to be something seem forward that would. You have to take pride in that and also the job done Bell will require prove which he can squeeze between the offensive tackles show the guy can pass protect and cheap team jerseys from China for you to square his shoulders leave his upright running style for outside field.

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