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SPINAL CORD STIMULATION FOR WEIGHT LOSS AND OBESITY

SPINAL CORD STIMULATION FOR WEIGHT LOSS AND OBESITY

Spinal Cord Electrical Stimulation for Obesity: A Preliminary Rodent Study (99)

Geng-Qing Song, Veterans Research and Education Foundation, Oklahoma City, OK; Jiande Chen, MD PhD, Veterans Research and Education Foundation, Oklahoma City, OK

Introduction: Spinal cord electrical stimulation (SCS) has been applied for the management of chronic pain . Most studies have revealed a decrease in sympathetic activity with SCS . In this study, we hypothesize that SCS with appropriate parameters and specific locations might increase sympathetic activity (causing an increase in metabolism and thus a decrease in body weight) and inhibited gastrointestinal motility (leading to early satiety with reduced food intake) .

Aims: The aim of this study was to investigate the effect of SCS on heart rates, sympathetic activity, serum norepinephrine, gastric emptying, and food intake in rats .

Methods: Male rats chronically implanted with SCS electrodes at T1/T2 or T5/T6 were studied in three experiments . Experiment 1 was to study the effects of SCS with different parameters and locations on heart rates, sympathetic activity . Experiment 2 was to assess the effect of SCS on serum norepinephrine and gastric emptying . Experiment 3 was to assess the effects of SCS on food intake . The animals received 5 days of either sham-SCS or SCS in a randomized order .

Results: (1) SCS at T1-T2 or T5-T6 of the 90% MT, 0 .1 ms, 100 Hz (but not 20 or 80 Hz) increased heart rates and sympathova- gal balance . Heart rate was 462 .4 ± 8 .2 beats/min or 466 .0 ± 9 .7 beats/min at baseline and increased to 477 .8 ± 9 .5 beats/min
(P = 0 .011, SCS at T1/T2) or 479 .9 ± 9 .8 beats/min (P = 0 .013, SCS at T1/T2), respectively . Similarly, the sympathovagal balance was 0 .43 ± 0 .03 or 0 .46 ± 0 .04 at baseline and increased to 0 .50 ± 0 .06 (P = 0 .018, SCS at T1/T2) or 0 .51 ± 0 .03 (P = 0 .012, SCS at T5/T6) , respectively . (2) SCS at T1-T2 or T5-T6 of the 90% MT, 0 .1 ms, 100 Hz increased serum norepinephrine by 98 .8% or 100 .8%, respectively, in comparison with baseline before SCS . (3) SCS at T5-T6 but not T1-T2 of the 90% MT, 0 .1 ms, 100 Hz de- layed gastric emptying . Gastric emptying was 60 .0% ± 3 .7% in the controls and decreased to 50 .4% ± 4 .8% with SCS at T5-T6 (P = 0 .042, vs . controls) . (4) SCS at T5-T6 of the 90% MT, 0 .1 ms, 100 Hz reduced daily food intake by 17 .8% (P = 0 .046) .

Conclusion: SCS at T5-T6 with appropriate parameters reduces food intake in regular rats and the inhibitory effect may attrib- uted to increased sympathetic activity and reduced gastric emptying . Further studies are warranted to explore the potential of SCS for obesity .

Disclosures: J. Chen: None . G. Song: None .

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